„Polypill“ u seniorov: možná frekvencia používania fixných kombinácií liečiv podľa údajov zo štúdie SAFIS / Polypill in seniors: possible frequency of fixed drug combination according to the SAFIS study

The Cardiology Pub Date : 2020-01-01 DOI:10.4149/cardiol_2020_2_7

M. Dúbrava, F. Németh, T. Drobná, L. Gerlich

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Abstract

Dubrava M, Nemeth F, Drobna T, Gerlich L. Polypill in seniors: possible frequency of fixed drug combination according to the SAFIS study. Cardiology Lett. 2020;29(2):97–101 Abstract. Aims: Polypharmacy is one of the most typical features of geriatrics. Unreliable drug usage belongs to its risks, among others. One way of reducing this risk is to integrate more drugs into one tablet (polypill). Nowadays this could be done especially in cardiovascular medicine. Real world data from the health care provided in Slovakia, which would reflect the potential for switching from more tabs with one drug towards the polypill in seniors, are almost unknown. Methods: We used the “Slovak Audit of atrial FIbrillation Study” (SAFIS) data (3 706 patients, average age 80.5 years) and evaluated how frequently patients had the combination of an angiotensin converting enzyme inhibitor (ACEI) or an AT1-receptor for angiotensin II inhibitor (ARB) and a diuretic, an ACEI/ARB and a betablocker (BB), an ACEI/ARB and a statin or at least 3 out of these 4 drug groups at discharge. Results: The average number of recommended drugs was 9.1 at discharge. A diuretic, BB, statin or ACEI/ ARB was recommended in 68.9, 64.1, 31.9 and 52.4% of patients respectively. Simultaneous treatment with a diuretic and an ACEI/ARB, BB and an ACEI/ARB, statin and an ACEI/ARB was recommended in 37.9, 36.2, and 19.7% patients respectively. The frequency of these co-treatments was typically higher than 40% in 65-79 yrs. old, declining with age moderately, but staying above 20% even in the oldest (90 yrs. and older) for combinations of an ACEI/ARB with a diuretic or a BB. At least 3 drugs from the groups ACEI/ARB, BB, diuretics, statins were recommended in 38.6% of patients. Conclusion: The potential for the reduction of the number of daily used tablets with their integration in a polypill is really high in seniors. Fig. 1, Tab. 1, Ref. 20, on-line full text (Free, PDF) www.cardiologyletters.sk

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Dubrava M, Nemeth F, Drobna T, Gerlich L.老年人多药片:根据SAFIS研究，固定药物联合的可能频率。心内科杂志，2020;29(2):97-101目的:多种用药是老年医学最典型的特征之一。不可靠的药物使用属于其风险之一。降低这种风险的一种方法是将更多的药物整合到一片药片中(复方药片)。现在这可以做到，特别是在心血管医学。斯洛伐克提供的卫生保健的真实世界数据几乎是未知的，这些数据将反映老年人从使用一种药物的多片药物转向使用复合药片的可能性。方法:我们使用“斯洛伐克房颤审计研究”(SAFIS)的数据(3706例患者，平均年龄80.5岁)，并评估患者在出院时联合使用血管紧张素转换酶抑制剂(ACEI)或血管紧张素II抑制剂(ARB)的at1受体和利尿剂、ACEI/ARB和β受体阻滞剂(BB)、ACEI/ARB和他汀类药物或这4种药物组中至少3种的频率。结果:出院时平均推荐药物为9.1种。分别有68.9、64.1、31.9和52.4%的患者推荐利尿剂、BB、他汀类药物或ACEI/ ARB。推荐同时使用利尿剂和ACEI/ARB、BB和ACEI/ARB、他汀类药物和ACEI/ARB的患者分别为37.9%、36.2%和19.7%。在65-79岁期间，这些联合治疗的频率通常高于40%。老年，随着年龄的增长而适度下降，但即使是最老的(90岁)也保持在20%以上。ACEI/ARB与利尿剂或BB的联合用药。38.6%的患者至少推荐ACEI/ARB、BB、利尿剂、他汀类药物组中的3种药物。结论:在老年人中，将其整合成复方片剂，减少日用量的潜力很大。图1，表1，参考文献20，在线全文(免费，PDF) www.cardiologyletters.sk

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The Cardiology

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