Review on obsessive-compulsive disorder

Abstract

OCD is a syndrome characterized by obsessions and compulsions, as well as other neuropsychiatric features, and is often associated with primary psychiatric disorders and various neurologic conditions. If severe, OCD can seriously interfere with the patient’s quality of life. The mainstay of treatment is psychotherapy, especially cognitive-behavioural therapy, and pharmacologic interventions, especially selective serotonin reuptake inhibitors (SSRIs). Unfortunately, a significant proportion of patients are refractory to these treatment modalities. A new understanding abuts the neurobiology of OCD has led to novel investigational treatments, especially neuromodulation techniques.