Photosensitizers and photochemistry (Conference Presentation)

Abstract

We will discuss product target profiles that photosensitizers for PDT should met to satisfy the requirements of clinical PDT. Next, we will review the spectroscopy and photochemistry of the main families of photosensitizers with an impact in clinical PDT. We will critically examine the factors that made such photosensitizers appealing for PDT and their shortcomings. Finally, an overview of opportunities ahead will be presented. Topics addressed – The phototherapeutic window – Electronic spectroscopy of porphyrin derivatives, phthalocyanines and BODIPYs – Photochemistry and ROS – Factors contributing to the performance of PDT sensitizers