Systematic review: Superparamagnetic Iron Oxide nanoparticles as contrast agents in diagnosis of multiple sclerosis

IF 1.2 Q4 NANOSCIENCE & NANOTECHNOLOGY
F. Fathi, M. Sadjadi, M. G. Cherati
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引用次数: 4

Abstract

Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as good CAs in recent years because of biocompatibility, low level of toxicity, magnetic properties, simple synthesis and coating to use in medical diagnosis. Uncoated magnetite nanonoparticles are insoluble in water. Hydrophilic coatings result water solubility of nanoparticles and prolonged circulation half-lives of SPION and reduce recognition by RES. SPIONs have an important role in diagnosis of multiple sclerosis (MS) by MRI. SPIONs are MRI contrast agents better than gadolinium because, SPIONs taken up by macrophages but not Gd-nanoparticles.
系统综述:超顺磁性氧化铁纳米颗粒作为对比剂在多发性硬化症诊断中的应用
几种MRI造影剂(CAs)用于医学诊断,其中钆(Gd3+)是应用最广泛的造影剂。不幸的是,它的毒性是由于效率低下。本文就SPIONs在MRI中的应用及其在多发性硬化症诊断中的应用作一综述。超顺磁性氧化铁纳米粒子(SPIONs)以其生物相容性好、毒性低、磁性强、合成简单、涂层方便等优点,近年来被广泛应用于医学诊断领域。未涂覆的磁铁矿纳米颗粒不溶于水。亲水涂层使纳米粒子具有水溶性,延长了SPION的循环半衰期,降低了res对SPION的识别。SPION在多发性硬化症(MS)的MRI诊断中具有重要作用。SPIONs是比钆更好的MRI造影剂,因为SPIONs被巨噬细胞吸收,而不是gd纳米颗粒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
international journal of nano dimension
international journal of nano dimension NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
2.80
自引率
20.00%
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