Advanced pancreatic cancer: diagnosis and systemic treatment evolution over the last decades

Abstract

Pancreatic cancer is one of common malignant neoplasms. It is characterised by poor prognosis and high mortality, which is mainly due to detection in advanced stage. The review presents the epidemiological and clinical characteristics of pancreatic cancer as well as current strategies of systemic treatment of advanced disease, including firstand second-line chemotherapy as well as molecularly targeted therapies and immunotherapy.