Effects of Dietary Pyrazinamide on the Growth of Weanling Rats Fed with a Nicotinic Acid-free and Tryptophan-limited Diet

Abstract

Pyrazinamide is a strong inhibitor of aminocarboxymuconate semialdehyde decarboxylase (ACMSDase; EC 4.1.1.45) in vivo,1] which activity is thought to be critical in tryptophan-nicotinamide conversion.2 ~ 5) I reported that an intraperitoneal injection of pyrazinamide to rats fed with a nicotinic acid-free and 20% casein diet greatly increased urinary excretion of nicotinamide and its catabolic metabolites such as A^-methylnicotinamide (MNA), ^V 1-methyl-2-pyridone-5-carboxamide (2-Py), and Table I. Composition of Diets 3111