Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review

Head & neck surgery Pub Date : 2022-04-20 DOI:10.1002/hed.27062

G. Mannelli, L. Comini, A. Sacchetto, R. Santoro, G. Spinelli, P. Bonomo, I. Desideri, P. Bossi, E. Orlandi, Giammarco Alderotti, A. Franchi, A. Palomba, A. Eccher, D. Marchioni, Riccardo Nocini, C. Piazza, G. Molteni

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引用次数: 2

Abstract

Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty‐five patients underwent salvage surgery (20.1%) and their 5‐year mortality rate, overall survival and disease‐free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow‐up.

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评估复发性唾液腺癌抢救手术后的生存率:系统综述

复发性唾液腺癌(RSCs)的特征不明确，其临床特征和治疗方案尚未得到充分描述。本研究的目的是通过文献回顾分析，分析RSC患者的治疗策略和肿瘤预后。该系统评价是根据PRISMA声明进行的。系统评价的纳入标准基于人群、干预、比较和根据(PICO)框架的结果。选取了2704条记录，并研究了1817条重复记录。365例患者接受了补救性手术(20.1%)，他们的5年死亡率、总生存率和无病生存率分别为35%、70%和42%。RSCs是侵袭性肿瘤，远端转移率高(28.9%)。对于局部和/或区域复发有限的患者，即使是在随访的前3年内出现单一远端复发，也可以考虑进行挽救性手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Head & neck surgery

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