SEX DIFFERENCES IN THE LEVELS OF MARKERS OF ENDOGENOUS INTOXICATION IN RATS WITH EXPERIMENTAL OBESITY UNDER CONDITION OF PREVENTIVE ADMINISTRATION OF ORLISTAT AND BIONANOCOMPOSITE BASED ON FENUGREEK

Abstract

Obesity is a complex disease involving an excessive amount of body fat. Obesity is generally caused by eating too much and physical activity too little. High-calorie diet-induced obesity occurs in both sexes, but more pronounced changes in blood parameters associated with this disease are more common in men. However, the gender-specific mechanisms of obesity development are little known. Therefore, the purpose of our study was to determine the sex-specific response to the content of the middle mass molecules and oligopeptides in the serum of rats under conditions of highcalorie diet consumption and after administration of a bionanocomposite based on fenugreek and orlistat. To do this, we used a modified Gabrielian method and mathematical processing and statistical analysis of the results.