Significance of the Renin-Angiotensin System in Clinical Conditions

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Vedran Đambić, Đorđe Pojatić, Anto Stažić, Aleksandar Kibel
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引用次数: 4

Abstract

The renin-angiotensin system, in both its circulating and local tissue roles, is intertwined with multiple other regulatory and signalling mechanisms in various tissues and organ systems. It plays a central role in the normal regulation of arterial blood pressure and in the development of hypertension, which is an immense global public health burden and a crucial modifiable risk factor in the development of cardiovascular diseases. The renin-angiotensin system plays also important roles in a range of other clinical conditions such as heart failure, kidney failure, diabetes mellitus and others. Therapeutic interventions within the renin-angiotensin system include the use of medications such as angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists, which are well established and have been invaluable as clinically effective tools during many years of practical use. Additionally, numerous other therapeutic approaches targeting components of the renin-angiotensin system have been developed or are currently in development. This chapter will discuss details of the roles of this system in the most relevant clinical conditions.
肾素-血管紧张素系统在临床中的意义
肾素-血管紧张素系统在其循环和局部组织中的作用,与多种其他组织和器官系统中的调节和信号机制交织在一起。它在动脉血压的正常调节和高血压的发展中起着核心作用,高血压是一个巨大的全球公共卫生负担,也是心血管疾病发展中一个关键的可改变风险因素。肾素-血管紧张素系统在一系列其他临床疾病中也起着重要作用,如心力衰竭、肾衰竭、糖尿病等。肾素-血管紧张素系统的治疗干预包括血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂等药物的使用,这些药物在多年的实际使用中已经建立起来,并且作为临床有效的工具是无价的。此外,许多其他针对肾素-血管紧张素系统成分的治疗方法已经开发或正在开发中。本章将详细讨论该系统在最相关的临床条件下的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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