Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey

Abstract

Background: The aims of this study were to evaluate the microbiological data for effective infection control and specific antimicrobial stewardship, and to report the epidemiology of intensive care unit (ICU)-acquired infections and the local antimicrobial resistance of pathogens Methods: Data were collected between January 2011 and October 2016 from the cardiology and cardiovascular surgery patients. The identification and antimicrobial susceptibility analyses of clinical pathogenic isolates were determined by the automatic device system. Results: Klebsiella pneumoniae was detected increasingly and significantly (p=0.048) resistant to imipenem (IMP). Acinetobacter baumanii was found increasingly and significantly (p=0.045, p=0.030, p=0.006, p=0.027) resistant to amikacin (AN), gentamicin (GN), trimethoprimsulfamethoxazole (SXT) and tetracycline (TE), respectively. There was a significantly decrease in the resistant rates of IMP, piperacillin-tazobactam (TPZ), meropenem (MEM) and ciprofloxacin (CIP) for Pseudomonas spp. (p=0.048). All gram-negative bacteria isolates showed significantly increasing resistance rates to cefepime (CEP) (p=0.015). Also, all gram-positive bacteria demonstrated significantly decreasing resistance rates to teicoplanin (TEC) (p=0.034). Conclusion: This study suggets that inadequacy of infection control measures such as hand hygiene and patient isolation may have contributed to increasing the rates of carbapenem-resistant K. pnemoniae (CR-KP) isolates in recent years. Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey Sanem Karadag Gecgel1, Necmiye Demircan2 1 Departments of Microbiology and Clinical Microbiology, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. 2 Departments of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. Contact information: Sanem Karadag Gecgel.  sanemkaradag@yahoo.com