Effect of Immunoglobulin for Childhood Severe Mycoplasm Pneumonia

Abstract

Objective To observe the clinical curative effect and safety of human immunoglobulin for intravenous injection in treating childhood severe mycoplasm pneumonia.Methods One hundred and thirty three children with severe mycoplasm pneumonia in clinic and wards of this hospital from October 2010 to November 2011 were randomly divided into treatment group(n=56) and control group(n=57).All the patients were administered with erythromycin,azithromycin and symptomatic treatment for two weeks.The treatment group also received human immunoglobulin for intravenous injection 400 mg/(kg·d) for 3 days compared to the control group.Results The symptom-free period of fever,cough,wheeze and wet rales in the treatment group were(2.1±1.3)d,(4.2±1.2)d,(2.5±1.2)d and(3.6±1.1)d,respectively;and in the control group(3.3±1.0)d,(5.6±2.3)d,(4.3±2.5)d and(5.4±1.8)d,respectively.The difference between the two group was statistically significant(P0.01).Conclusion Human immunoglobulin for intravenous injection has a greater efficacy and fewer side effects on children with mycoplasm pneumonia.