Incorporation of Nanoparticles Based on Zingiber Officinale Essential Oil into Alginate Films for Sustained Release

IF 1.2 Q3 MULTIDISCIPLINARY SCIENCES

Journal of Physical Science Pub Date : 2022-08-25 DOI:10.21315/jps2022.33.2.7

N. Rosli, German A. Islan, R. Hasham, Guillermo R. Castro, Azila Abdul Aziz

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Abstract

This research focused on the formulation of Ca2+ cross-linked alginate (Alg) gels containing Zingiber officinale oil extract (ZOE) loaded into a nanostructured lipid carrier (NLC). The NLC is intended to protect the Zingiber officinale oil against physical and chemical degradation during topical administration to sustain the drug release and reduce drug leakage during storage. The NLC was prepared using hot homogenisation and ultrasonication of glyceryl monostearate. Virgin coconut oil was used as the liquid lipid. The NLC-ZOE had a mean size diameter of 100 nm and a zeta potential value of −40 mV. The ZOE released from NLC followed the Korsmeyer- Peppas model case I (Fickian diffusion). The NLC-ZOE formulation was then incorporated into Alg. The gels were prepared via ionotropic gelation in the presence of calcium. Scanning electron microscopy (SEM) images of Alg films revealed successful intercalation of NLC within the Alg matrix. The in vitro ZOE release from NLC-ZOEAlg occurred in a sustained manner from the cross-linked Alg hydrogels compared to the free NLC. The profiles of NLC-ZOE released from the Alg films depended on the nanoparticles amount. The results demonstrated the importance of designing a local delivery system to entrap and control the release of the bioactive components of ZOE from within the Alg matrix. Ca2+ cross-linked Alg gels containing ZOE loaded into NLC was found to be suitable for topical delivery applications, as shown by the sustained release of ZOE from calcium cross-linked Alg films containing NLC that was demonstrated in this study.

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基于铁皮姜精油纳米颗粒的海藻酸盐膜缓释研究

本研究主要研究了钙+交联海藻酸盐(Alg)凝胶的配方，该凝胶将生姜油提取物(ZOE)装载到纳米结构脂质载体(NLC)中。NLC旨在保护生姜油在外用过程中免受物理和化学降解，以维持药物释放并减少药物在储存过程中的泄漏。采用热均质和超声法制备了单硬脂酸甘油酯。用初榨椰子油作为液体脂质。NLC-ZOE的平均粒径为100 nm, zeta电位值为- 40 mV。NLC释放的ZOE遵循Korsmeyer- Peppas模型情况I (Fickian扩散)。然后将NLC-ZOE配方加入Alg。在钙的存在下，通过离子化凝胶法制备了凝胶。扫描电子显微镜(SEM)图像显示，NLC成功嵌入到Alg基质中。与游离的NLC相比，交联的Alg水凝胶可以持续释放NLC- zoealg的ZOE。NLC-ZOE在Alg膜上的分布与纳米颗粒的添加量有关。结果表明，设计一种局部递送系统来捕获和控制ZOE生物活性成分从藻类基质中释放的重要性。将含有ZOE的Ca2+交联Alg凝胶加载到NLC中，被发现适合局部给药应用，正如本研究中证明的，ZOE从含有NLC的钙交联Alg膜中持续释放出来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physical Science Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The aim of the journal is to disseminate latest scientific ideas and findings in the field of physical sciences among scientists in Malaysia and international regions. This journal is devoted to the publication of articles dealing with research works in Chemistry, Physics and Engineering. Review articles will also be considered. Manuscripts must be of scientific value and will be submitted to independent referees for review. Contributions must be written in English and must not have been published elsewhere.