Antibacterial and Antioxidant Phenylpropanoid Derivative from the Leaves of Plantago lanceolate

Firew Deribew, Milkyas Endale, Y. Melaku
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引用次数: 4

Abstract

Plantago lanceolata (Plantaginaceae) is a perennial cosmopolitan species traditionally used for blood clotting and healing of wound. The powdered leaves were successively extracted with n-hexane, ethyl acetate and methanol to give 1.55, 2.16, and 8.2%, yield, respectively. Silica gel column chromatography afforded one phenylpropanoid derivative named verbascoside. The structure of the compound was determined using spectroscopic methods (UVVis, IR, NMR). The extracts, and verbascoside were evaluated invitro for antibacterial activities by using the disc diffusion method against Staphylococcus aureus, Escherichia coli, Klebsiella pneumania and Proteus miabilis. The promising inhibition zone (20 mm) was observed by verbascoside against S. aureus compared to standard Ciprofloxacin (23 mm). The radical scavenging activity of the methanol and ethyl acetate extract, and verbascoside compounds were 64.2%, 79.2 and 83.9, respectively suggesting that verbascoside displayed powerful radical scavenging activity indicating the potential of the plant as herbal remedies.
从披针形车前草叶中提取的抗菌和抗氧化苯丙类衍生物
车前草(车前草科)是一种多年生世界性植物,传统上用于凝血和伤口愈合。分别用正己烷、乙酸乙酯和甲醇提取叶粉,得率分别为1.55%、2.16%和8.2%。硅胶柱层析得到一种苯基丙烷衍生物,命名为毛蕊花苷。用光谱法(紫外、红外、核磁共振)测定了化合物的结构。采用圆盘扩散法对金葡萄球菌、大肠杆菌、肺炎克雷伯菌和变形杆菌进行体外抑菌活性评价。与标准环丙沙星(23 mm)相比,毛蕊花糖苷对金黄色葡萄球菌的抑制带为20 mm。甲醇和乙酸乙酯提取物和毛蕊花糖苷化合物的自由基清除活性分别为64.2%、79.2和83.9,表明毛蕊花糖苷具有较强的自由基清除能力,具有作为中药的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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