An acrylamide-based molecularly imprinted polymer for the efficient recognition of optical amino acid hydantoins

Jie Zhou, Xiwen He, Yijun Li
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引用次数: 14

Abstract

Using acrylamide as a hydrogen bonding functional monomer and (5R)-5-benzylhydantoin as a template, a molecularly imprinted polymer was prepared in a polar solvent, which exhibited good enantiomeric recognition properties. The binding selectivity of the polymer was evaluated by batch methods. Scatchard analyses showed that two classes of binding sites were produced in the imprinted polymer and their dissociation constants were estimated to be (4.6 ± 0.8) × 10–5 and (1.3 ± 0.2) × 10–4 mol L–1, respectively. This was in agreement with the prediction of the binding characteristics of the polymer by a spectrophotometric method. Study of the effect of water on the separation factor of the polymer further proved that the hydrogen bonding interactions played an important role in the recognition of acrylamide-based molecularly imprinted polymers.
一种基于丙烯酰胺的分子印迹聚合物,用于光学氨基酸醛酸的高效识别
以丙烯酰胺为氢键功能单体,以(5R)-5-苄基海因为模板,在极性溶剂中制备了具有良好对映体识别性能的分子印迹聚合物。用批处理法评价了聚合物的结合选择性。Scatchard分析表明,印迹聚合物中产生了两类结合位点,其解离常数分别为(4.6±0.8)× 10-5和(1.3±0.2)× 10-4 mol L-1。这与分光光度法对聚合物结合特性的预测一致。水对聚合物分离因子影响的研究进一步证明了氢键相互作用对丙烯酰胺基分子印迹聚合物的识别起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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