Profil Toksikologis Ekstrak Daun Tumbuhan Baka-Baka (Hyptis capitata Jacq.) Pada Hati Tikus Putih (Rattus norvegicus)

Abstract

Hyptis capitata Jacq. plant has been using for traditional medicine. Utilization of medicinal plant must always consider to given dose because of toxic effect when too much medicine is taken. The aim of this study was to measure the liver damage in mouse caused by H. capitata Jacq. leave extract when it was given an excessive dose. Either 300 (P1), 600 (P2) or 900 (P3) µg H. capitata Jacq. leave extract was given orally to mice every 24 hours during 14 days. Zero point five ml ethanol 96% was given daily (K-) and without given anything (K+) was also conducted as a control. The result showed that mice given P3 treatment had the highest liver damage. The liver damage in mice was not statistically significant difference between P3 and K- treatments. The lowest liver damage was in mice given K+ treatment. There was no significant difference between P1 and P2 treatments on mice liver damage. Utilization of medicinal plant as traditional medicine should always be consider to doses.