Weihua Song, Wu Sun, Zilong Wang, K. Teo, C. Cheung, Xiaomeng Wang
{"title":"Targeting Inflammation to Control Tissue Fibrosis","authors":"Weihua Song, Wu Sun, Zilong Wang, K. Teo, C. Cheung, Xiaomeng Wang","doi":"10.53941/ijddp.v1i1.206","DOIUrl":null,"url":null,"abstract":"Review\nTargeting Inflammation to Control Tissue Fibrosis\n\nWeihua Song 1, Wu Sun 2, Zilong Wang 3, Kelvin Yi Chong Teo 2,4,5, Chui Ming Gemmy Cheung 2,4,5, and Xiaomeng Wang 4,5,6,*\n\n\n1 Innoland Biosciences, 6 West Beijing Road, Taicang 215400, Jiangsu, China.\n2 Singapore National Eye Center, 11 Third Hospital Ave 168751, Singapore.\n3 Ocean University of China, 5 Yushan Rd, Shinan District, Qingdao 266005, Shandong, China.\n4 Singapore Eye Research Institute, 20 College Road 169856, Singapore.\n5 Duke-NUS Graduate Medical School, 20 College Road 169856, Singapore.\n6 Insitute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos 138673, Singapore.\n* Correspondence: xiaomeng.wang@duke-nus.edu.sg\n \n \nReceived: 17 November 2022\nAccepted: 19 November 2022\nPublished: 21 December 2022\n \n\nAbstract: Remodeling of the extracellular matrix (ECM) is an essential process in host defense against pathogens and tissue repair following injury. However, aberrant inflammatory responses could disturb ECM homeostasis leading to progressive disruption in tissue architecture and organ function. Fibrosis is the common outcome of a wide range of diseases, especially chronic inflammatory disorders, and represents the leading cause of morbidity and mortality globally. This review provides the current understanding of the pathogenesis of fibrosis, with particular emphasis on the role of inflammation in this process and the translational potential of targeting inflammation as a strategy to control fibrotic progression.","PeriodicalId":94047,"journal":{"name":"International journal of drug discovery and pharmacology","volume":"93 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of drug discovery and pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53941/ijddp.v1i1.206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Review
Targeting Inflammation to Control Tissue Fibrosis
Weihua Song 1, Wu Sun 2, Zilong Wang 3, Kelvin Yi Chong Teo 2,4,5, Chui Ming Gemmy Cheung 2,4,5, and Xiaomeng Wang 4,5,6,*
1 Innoland Biosciences, 6 West Beijing Road, Taicang 215400, Jiangsu, China.
2 Singapore National Eye Center, 11 Third Hospital Ave 168751, Singapore.
3 Ocean University of China, 5 Yushan Rd, Shinan District, Qingdao 266005, Shandong, China.
4 Singapore Eye Research Institute, 20 College Road 169856, Singapore.
5 Duke-NUS Graduate Medical School, 20 College Road 169856, Singapore.
6 Insitute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos 138673, Singapore.
* Correspondence: xiaomeng.wang@duke-nus.edu.sg
Received: 17 November 2022
Accepted: 19 November 2022
Published: 21 December 2022
Abstract: Remodeling of the extracellular matrix (ECM) is an essential process in host defense against pathogens and tissue repair following injury. However, aberrant inflammatory responses could disturb ECM homeostasis leading to progressive disruption in tissue architecture and organ function. Fibrosis is the common outcome of a wide range of diseases, especially chronic inflammatory disorders, and represents the leading cause of morbidity and mortality globally. This review provides the current understanding of the pathogenesis of fibrosis, with particular emphasis on the role of inflammation in this process and the translational potential of targeting inflammation as a strategy to control fibrotic progression.