Survival analysis of patients with acute liver failure after liver transplantation

Chineae Journal of Organ Transplantation Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.0254-1785.2019.11.007

Xingqiang Wang, Yi-he Liu, Li-xin Yu, Yan Sun

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Abstract

Objective To explore the clinical efficacy and risk factors of mortality for liver transplantation in patients with acute liver failure. Methods From January 2012 to December 2017, retrospective analysis was performed for 31 patients with acute liver failure undergoing orthotopic liver transplantation. Clinical data and follow-up data were recorded. Univariate survival analysis was performed by Kaplan-Meier and Log-rank tests while multivariate survival analysis conducted by proportional hazards model. Results Age ≥55 years, preoperative hepatorenal syndrome, perioperative infection and preoperative non-molecular adsorbent recirculating system (MARS) support were influencing factors of postoperative survival rate by univariate survival analysis (P<0.05). Preoperative infection was an independent risk factor for survival after liver transplantation by multivariate COX regression analysis (P<0.01). Conclusions Liver transplantation is an effective treatment for acute liver failure. And preoperative infection is an independent risk factor for survival after liver transplantation. Key words: Liver failure; Acute; Liver transplantation; Survival analysis

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肝移植术后急性肝功能衰竭患者的生存分析

目的探讨急性肝功能衰竭患者肝移植的临床疗效及死亡危险因素。方法回顾性分析2012年1月至2017年12月31例急性肝功能衰竭患者行原位肝移植的临床资料。记录临床资料及随访资料。单因素生存分析采用Kaplan-Meier检验和Log-rank检验，多因素生存分析采用比例风险模型。结果单因素生存分析显示，年龄≥55岁、术前肝肾综合征、围手术期感染、术前非分子吸附剂再循环系统(MARS)支持是影响术后生存率的因素(P<0.05)。多因素COX回归分析显示，术前感染是影响肝移植术后生存的独立危险因素(P<0.01)。结论肝移植是治疗急性肝衰竭的有效方法。术前感染是影响肝移植术后生存的独立危险因素。关键词:肝衰竭;急性的;肝移植;生存分析

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Chineae Journal of Organ Transplantation

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