Synthesis, structural characterization, and initial anticancer activity of water soluble polyethers from hafnocene dichloride and poly(ethylene glycols)

Abstract

ABSTRACTThe initial synthesis of DMSO and water-soluble hafnocene polyethers is described. The polyethers are formed through reaction of the hafnocene dichloride with various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the hafnocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1200 to 8 with moderate product yield. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines.