Comparison of efficacy of oxaliplatin versus paclitaxel in combination with 5-fluorouracil chemotherapy in patients with gastric cancer after radical operation

Central Plains Medical Journal Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1674-4756.2020.04.033

Hongduo Jiao, Ruinuo Jia, Lingling Zhang, Bian-Ying Li

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Abstract

Objective To compare and analyze the chemotherapy value of oxaliplatin + 5-fluorouracil and paclitaxel + 5-fluorouracil after radical gastrectomy. Methods A total of 150 patients with gastric cancer who underwent radical gastrectomy in the First Affiliated Hospital of Henan University of Science and Technology from January 2014 to July 2016 were divided into study group (n=75) and control group (n=75). The patients in study group received oxaliplatin + 5-fluorouracil chemotherapy and the patients in control group received paclitaxel + 5-fluorouracil chemotherapy. The long-term effect, adverse reactions and quality of life of the two groups were recorded. Results The progression free survival time was compared between the two groups, the difference was not statistically significant (P>0.05); the recurrence rate, tumor free survival rate, metastasis rate and mortality were compared between the two groups, the differences were not statistically significant (P>0.05); chemotherapy drug-related myelosuppression (25.33%) and elevation of alanine aminotransferase (1.33%) in study group were lower than those in control group (49.33%, 9.33%), the differences were not statistically significant (P>0.05); adverse reactions of other chemotherapy drugs between the two groups were compared, the differences were not statistically significant (P>0.05); WHOQOL-100 scores were compared between the two groups before chemotherapy, the differences were not statistically significant (P>0.05); the score of WHOQOL-100 in the control group after chemotherapy was significantly lower than that before chemotherapy (P<0.05). Conclusions Chemotherapy with oxaliplatin + 5-fluorouracil and paclitaxel + 5-fluorouracil is effective after radical gastrectomy for gastric cancer, but the former is safe and beneficial to the quality of life of patients. Key words: Gastric cancer; Oxaliplatin; Paclitaxel; 5-fluorouracil; Radical operation

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胃癌根治术后奥沙利铂与紫杉醇联合5-氟尿嘧啶化疗的疗效比较

目的比较分析奥沙利铂+ 5-氟尿嘧啶与紫杉醇+ 5-氟尿嘧啶在胃癌根治术后的化疗价值。方法选取2014年1月至2016年7月在河南科技大学第一附属医院行根治性胃切除术的胃癌患者150例，分为研究组(n=75)和对照组(n=75)。研究组患者采用奥沙利铂+ 5-氟尿嘧啶化疗，对照组患者采用紫杉醇+ 5-氟尿嘧啶化疗。记录两组患者的远期疗效、不良反应及生活质量。结果两组患者无进展生存时间比较，差异无统计学意义(P>0.05);两组患者复发率、无瘤生存率、转移率、死亡率比较，差异均无统计学意义(P>0.05);研究组化疗药物相关骨髓抑制(25.33%)、丙氨酸转氨酶升高(1.33%)均低于对照组(49.33%、9.33%)，差异无统计学意义(P>0.05);比较两组患者其他化疗药物不良反应情况，差异无统计学意义(P>0.05);化疗前比较两组患者WHOQOL-100评分，差异均无统计学意义(P>0.05);对照组化疗后WHOQOL-100评分显著低于化疗前(P<0.05)。结论奥沙利铂+ 5-氟尿嘧啶和紫杉醇+ 5-氟尿嘧啶是胃癌根治后化疗的有效方案，但前者安全且有利于提高患者的生活质量。关键词:胃癌;铂;紫杉醇;5 -氟尿嘧啶;根治手术

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Central Plains Medical Journal

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