Magnetic Resonance Diffusion-Weighted Imaging to Evaluate the Clinical Efficacy of CalliSpheres Drug-Loaded Microspheres in the Treatment of Advanced Bladder Cancer

IF 0.4 4区化学 Q4 CHEMISTRY, PHYSICAL

Concepts in Magnetic Resonance Part A Pub Date : 2023-02-10 DOI:10.1155/2023/2996498

Xi Yang, Wei Chen

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引用次数: 0

Abstract

The MR diffusion-weighted imaging technique was used to evaluate the efficacy and safety of CalliSpheres drug-loaded microspheres for transarterial chemoembolization in the treatment of advanced bladder cancer. 35 patients with advanced bladder cancer were treated with CalliSpheres DLMS for transarterial chemoembolization. Imaging techniques such as magnetic resonance (MR) diffusion-weighted imaging were used to evaluate the therapeutic effect. The changes in serum tumor markers, immune function indexes, and oxidative stress indexes in patients before and after treatment were compared, and the quality of life of patients and the incidence of adverse reactions during follow-up were also evaluated. The results showed that the overall response rate (ORR) was 74.29% and that the disease control rate (DCR) was 97.14%. Compared with that before treatment, the ADC value of the tumor in patients with advanced bladder cancer detected by MR diffusion-weighted imaging technology was significantly increased after treatment and the maximum tumor diameter was significantly decreased P < 0.05 . Compared with those before treatment, the levels of serum tumor markers (CA199, CA724, and CA125) in advanced bladder cancer patients after treatment decreased P < 0.05 . The levels of T-lymphocyte subsets (CD3+ and CD4+) decreased, and CD8+ levels increased P < 0.05 . The levels of superoxide dismutase decreased P > 0.05 . At the same time, the subscale evaluation of function, symptoms, quality of life, adverse reactions, and economics of patients with advanced bladder cancer on the QLQ-C30 scale improved after treatment, and the incidence rate and recurrence rate during the follow-up period were 8.57% and 11.43%, respectively. It showed that CalliSpheres DLMS had a good clinical effect and high safety in the treatment of advanced bladder cancer and was a safe and feasible treatment method. The use of MR diffusion-weighted imaging technology could achieve quantitative evaluation of clinical efficacy of advanced bladder cancer.

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磁共振弥散加权成像评价CalliSpheres载药微球治疗晚期膀胱癌的临床疗效

采用磁共振弥散加权成像技术评价CalliSpheres载药微球经动脉化疗栓塞治疗晚期膀胱癌的疗效和安全性。应用calispheres DLMS经动脉化疗栓塞治疗晚期膀胱癌35例。影像学技术如磁共振(MR)弥散加权成像评估治疗效果。比较患者治疗前后血清肿瘤标志物、免疫功能指标、氧化应激指标的变化，并评价随访期间患者的生活质量及不良反应发生情况。结果显示，总有效率(ORR)为74.29%，疾病控制率(DCR)为97.14%。与治疗前相比，治疗后晚期膀胱癌患者MR弥散加权成像技术检测肿瘤的ADC值显著升高，最大肿瘤直径显著降低(P < 0.05)。同时，治疗后QLQ-C30量表对晚期膀胱癌患者功能、症状、生活质量、不良反应、经济的亚量表评价均有所改善，随访期间发病率和复发率分别为8.57%和11.43%。说明CalliSpheres DLMS治疗晚期膀胱癌临床效果好，安全性高，是一种安全可行的治疗方法。应用磁共振弥散加权成像技术可以定量评价晚期膀胱癌的临床疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Concepts in Magnetic Resonance Part A 物理-光谱学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Concepts in Magnetic Resonance Part A brings together clinicians, chemists, and physicists involved in the application of magnetic resonance techniques. The journal welcomes contributions predominantly from the fields of magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), but also encourages submissions relating to less common magnetic resonance imaging and analytical methods. Contributors come from academic, governmental, and clinical communities, to disseminate the latest important experimental results from medical, non-medical, and analytical magnetic resonance methods, as well as related computational and theoretical advances. Subject areas include (but are by no means limited to): -Fundamental advances in the understanding of magnetic resonance -Experimental results from magnetic resonance imaging (including MRI and its specialized applications) -Experimental results from magnetic resonance spectroscopy (including NMR, EPR, and their specialized applications) -Computational and theoretical support and prediction for experimental results -Focused reviews providing commentary and discussion on recent results and developments in topical areas of investigation -Reviews of magnetic resonance approaches with a tutorial or educational approach