Role of Probiotics and Gut microbiota in Liver Diseases

Abstract

The complex combination of numerous microbes present in the GI tract of human being is referred to as Gut microbiota, consists of almost 1000 microbial cells, that is almost many times higher than that of human tissues in a person. The intestinal microbiota in each person has a completely unique blend of species. Trillions of microbes are present in the human body which include both beneficial and dangerous organisms. The microbiota plays a crucial role in nutritional status, immune level and effects on the behaviour and cognitive development. The human gastrointestinal tract has many bacterial species, provides a microbial barrier in opposition to potential pathogens and it regulates the frame's immune responses. The gut microbiota composition has a major function in the occurrence of liver illnesses. Variations within the gut microbiota seem to have an important position in the pathogenesis and progression of many gastrointestinal and liver sicknesses. Alterations within the features of liver-intestine axis can cause release of pro-inflammatory cytokines and autoimmune responses inside the liver which can have deleterious impact on liver cells. Administration of health enhancing microbes may ameliorate dangerous interactions and hepatic disorders. This review addresses the role of intestine microbiota in hepatic diseases and the impact of probiotics in the management of hepatic diseases.