Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

R. Z. Hamza, Shaden E. Al-Motaani, Tarek Al-Talhi
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引用次数: 7

Abstract

Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in wound healing. Many methods of treatment have recently been employed for novel dressings for the promotion of tissue regeneration and rapid wound closure. Combretum molle is composed of chemical compounds, such as lignin, gallic acid, and ellagic acid. Twenty male rats that were 4 months of age were divided into a I-a diabetic foot ulcer group as the control group and a II-a diabetic group (wound + Combretum molle). This study investigated the antioxidant and excellent healing effects of the extract of Combretum molle in repairing skin damaged by diabetes. This was confirmed by elevated antioxidant enzymes in the animals’ tissues in diabetic rats treated with this extract. The recovery of the alterations in the skin layers led to great improvements, which proved the Combretum molle’s promising capacity for wound healing in diabetics with wounds that mimic diabetic foot ulcers. This treatment can be considered a promising opportunity for patients with severe foot ulcers and may open the door to more discoveries about this plant’s medical capabilities.
紫荆分子活性成分对糖尿病实验模型伤口的治疗和缓解作用
足部溃疡是糖尿病患者严重和高死亡率的主要原因之一。众所周知,糖尿病患者的创面愈合是一个非常复杂的过程,糖尿病对血管有直接严重的影响,创面愈合困难。许多治疗方法最近被用于新型敷料,以促进组织再生和快速伤口愈合。Combretum molle是由木质素、没食子酸、鞣花酸等化合物组成。选取4月龄雄性大鼠20只,分为I-a型糖尿病足溃疡组(对照组)和II-a型糖尿病足溃疡组(创面+ Combretum molle)。本研究探讨了龙葵提取物对糖尿病皮肤损伤的抗氧化及良好的修复作用。用这种提取物治疗的糖尿病大鼠的动物组织中抗氧化酶的升高证实了这一点。皮肤层变化的恢复带来了巨大的改善,这证明了Combretum molle在糖尿病患者的伤口愈合方面有希望的能力,这些伤口模仿糖尿病足溃疡。这种治疗方法可以被认为是严重足溃疡患者的一个有希望的机会,并可能打开大门,发现更多关于这种植物的医疗能力。
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