Design and Synthesis of Antifungal Compounds from 1,2,3-Triazoles through the Click Chemistry Approach

Abstract

1,2,3-triazoles are easily prepared from CuAAC reaction and represent a potential source of antifungal compounds analogous to azole drugs. Accordingly, research groups have synthesized diverse 1,2,3-triazoles with modulated antifungal activity through the substituents in azide or alkyne precursors. A brief review of the state of the art about this topic is presented, focusing the increasing importance of developing new and more selective antifungal compounds.