A COMPREHENSIVE REVIEW ON GASTRORETENTIVE FLOATING TABLET OF CAPTOPRIL USING NATURAL AND SYNTHETIC POLYMER WITH COMPARISION OF POLYMER EFFICACY

Abstract

The oral route of drug administration is the most important method of administering drug for systematic effect. The present study was undertaken to prolong the release of orally administer. Captopril in the floating tablets by using different grade of HPMC. Formulation were optimized using different viscosity grades of HPMC. Lactose and citric acid and also natural polymers chitosan and carbopole. were used in different concentration as a channeling and chelating agent to obtain best optimized formulation and designed to prolong the gastric residence time (GRT). KEYWORD: gastroretentive floating drung delivery system, Gastric retention time, HPMC, Lactose, Carbopole, Chitosan.