Sperm DNA damage causes, assessment and relationship with fertility: A review

Theriogenology Insight - An International Journal of Reproduction in all Animals Pub Date : 2017-01-01 DOI:10.5958/2277-3371.2017.00010.9

S. Lone, N. Shah, H. Yadav, M. A. Wagay, Ajeet Singh, R. Sinha

{"title":"Sperm DNA damage causes, assessment and relationship with fertility: A review","authors":"S. Lone, N. Shah, H. Yadav, M. A. Wagay, Ajeet Singh, R. Sinha","doi":"10.5958/2277-3371.2017.00010.9","DOIUrl":null,"url":null,"abstract":"Evaluation of sperm quality has been mainly based on subjective parameters included in the spermiogram. Results of these parameters have been correlated with fertility but this relationship is not always true. Recently, for bull fertility assessment, sperm DNA integrity assessment has been proposed as an important index. Sperm DNA integrity has got an important role in success of fertilization process and fetal and offspring development. DNA integrity assessment has got a pivotal role in assisted reproductive techniques such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), besides sperm quality assessment and putative fertility predictor. Various techniques for assessment of sperm DNA integrity have been proposed. Using various sperm DNA integrity assays for detection and characterization of DNA fragmentation will aid in improving semen storage procedures by identification of various protocols which are less likely to be associated with DNA damage. Moreover, sperm DNA assays may help in screening bulls that produce good freezable semen with reasonable fertility.","PeriodicalId":23078,"journal":{"name":"Theriogenology Insight - An International Journal of Reproduction in all Animals","volume":"30 1","pages":"13"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theriogenology Insight - An International Journal of Reproduction in all Animals","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5958/2277-3371.2017.00010.9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 6

Abstract

Evaluation of sperm quality has been mainly based on subjective parameters included in the spermiogram. Results of these parameters have been correlated with fertility but this relationship is not always true. Recently, for bull fertility assessment, sperm DNA integrity assessment has been proposed as an important index. Sperm DNA integrity has got an important role in success of fertilization process and fetal and offspring development. DNA integrity assessment has got a pivotal role in assisted reproductive techniques such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), besides sperm quality assessment and putative fertility predictor. Various techniques for assessment of sperm DNA integrity have been proposed. Using various sperm DNA integrity assays for detection and characterization of DNA fragmentation will aid in improving semen storage procedures by identification of various protocols which are less likely to be associated with DNA damage. Moreover, sperm DNA assays may help in screening bulls that produce good freezable semen with reasonable fertility.

查看原文本刊更多论文

精子DNA损伤的原因、评估及其与生育能力的关系综述

精子质量的评价主要基于精子图中的主观参数。这些参数的结果与生育力相关，但这种关系并不总是正确的。近年来，精子DNA完整性评价已被提出作为公牛生育能力评价的重要指标。精子DNA的完整性对受精过程的成功以及胎儿和后代的发育具有重要作用。DNA完整性评估在体外受精(IVF)、胞浆内单精子注射(ICSI)等辅助生殖技术中，除了评估精子质量和推测生育能力外，还具有关键作用。人们提出了各种评估精子DNA完整性的技术。使用各种精子DNA完整性分析来检测和表征DNA片段，将有助于通过识别不太可能与DNA损伤相关的各种方案来改进精液储存程序。此外，精子DNA分析可能有助于筛选公牛产生良好的冷冻精液和合理的生育能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Theriogenology Insight - An International Journal of Reproduction in all Animals

自引率

0.00%

发文量