Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

Journal of Solid Tumors Pub Date : 2021-09-25 DOI:10.5430/jst.v11n1p1

Shaza I.A. Hasan, Sherief Y.M. El Nagdy, M. Ibrahim

{"title":"Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)","authors":"Shaza I.A. Hasan, Sherief Y.M. El Nagdy, M. Ibrahim","doi":"10.5430/jst.v11n1p1","DOIUrl":null,"url":null,"abstract":"Background: Ameloblastoma is a common benign aggressive odontogenic tumor with a tendency for high recurrence rate. Ameloblastic Carcinoma is the malignant counterpart of Ameloblastoma. However, they are usually difficult to be distinguished from one another. Therefore, using Immunohistochemical markers might be beneficial for diagnosing them accurately.Objective: Evaluation of SOX2 and GPC3 expressions as well as evaluating their roles in the tumorigenesis and the biological behavior of Ameloblastoma and Ameloblastic Carcinoma.Methods: Tissue samples are composed of 34 archived histopathologically confirmed cases of (19 Conventional Ameloblastomas, and 15 Ameloblatic Carcinomas). Sections were subjected to Immunohistochemical staining according to a standard protocol by applying antibodies to SOX2, and GPC3.Results: SOX2 and GPC3 expressions in recurrent Ameloblastoma were significantly higher than non- recurrent cases. Ameloblastic Carcinoma showed the highest immune-reactivity to SOX2 and GPC3 compared to the Conventional Ameloblastoma. Desmoplastic Ameloblastoma showed the highest scores of SOX2 and GPC3 compared to the other subtypes.Conclusions: SOX2 and GPC3 can be used as a panel for diagnosing the aggressive and the malignant odontogenic tumors accurately. Desmoplastic Ameloblastoma behaves more aggressively than other Conventional Ameloblastoma subtypes.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"203 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solid Tumors","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5430/jst.v11n1p1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Ameloblastoma is a common benign aggressive odontogenic tumor with a tendency for high recurrence rate. Ameloblastic Carcinoma is the malignant counterpart of Ameloblastoma. However, they are usually difficult to be distinguished from one another. Therefore, using Immunohistochemical markers might be beneficial for diagnosing them accurately.Objective: Evaluation of SOX2 and GPC3 expressions as well as evaluating their roles in the tumorigenesis and the biological behavior of Ameloblastoma and Ameloblastic Carcinoma.Methods: Tissue samples are composed of 34 archived histopathologically confirmed cases of (19 Conventional Ameloblastomas, and 15 Ameloblatic Carcinomas). Sections were subjected to Immunohistochemical staining according to a standard protocol by applying antibodies to SOX2, and GPC3.Results: SOX2 and GPC3 expressions in recurrent Ameloblastoma were significantly higher than non- recurrent cases. Ameloblastic Carcinoma showed the highest immune-reactivity to SOX2 and GPC3 compared to the Conventional Ameloblastoma. Desmoplastic Ameloblastoma showed the highest scores of SOX2 and GPC3 compared to the other subtypes.Conclusions: SOX2 and GPC3 can be used as a panel for diagnosing the aggressive and the malignant odontogenic tumors accurately. Desmoplastic Ameloblastoma behaves more aggressively than other Conventional Ameloblastoma subtypes.

查看原文本刊更多论文

SOX2和GPC3在成釉细胞瘤及其恶性肿瘤(成釉细胞癌)中的预后意义

背景:成釉细胞瘤是一种常见的良性侵袭性牙源性肿瘤，复发率高。成釉细胞癌是与成釉细胞瘤相对应的恶性肿瘤。然而，它们通常很难相互区分。因此，使用免疫组织化学标记物可能有助于准确诊断。目的:探讨SOX2和GPC3在成釉细胞瘤和成釉细胞癌发生和生物学行为中的表达及意义。方法:选取34例经病理证实的组织标本(19例为常规成釉细胞瘤，15例为成釉细胞癌)。将SOX2和GPC3分别应用抗体，按照标准方案对切片进行免疫组化染色。结果:SOX2和GPC3在成釉细胞瘤复发组织中的表达明显高于非复发组织。与常规成釉细胞瘤相比，成釉细胞癌对SOX2和GPC3的免疫反应性最高。结缔组织增生成釉细胞瘤的SOX2和GPC3评分高于其他亚型。结论:SOX2和GPC3可作为牙源性肿瘤侵袭性和恶性肿瘤的准确诊断指标。结缔组织增生成釉细胞瘤比其他常规成釉细胞瘤亚型更具侵袭性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Solid Tumors

自引率

0.00%

发文量