A rare malignant tumor of corpus uterine: peripheral nerve sheath tumor (MPNST): Review and our experience

Abstract

Soft tissue and visceral sarcomas are rare tumors which often develop in muscles, joints, nerves, fat, skin, or vessels. In a significant proportion, they appear in the abdomen and in the female reproductive system. Considering that early-stage sarcomas do not give symptoms, there are often late diagnosed in a quite advanced and/or metastatic stage. Malignant peripheral nerve sheath tumors (MPNSTs) are an uncommon type of malignant soft tissue sarcomas. In this report, we refer to a rare case of histologically confirmed MPNST arisen from corpus uterus in a 74 years old woman. The above-mentioned patient was admitted with abdominal pain and severe vaginal bleeding. Firstly, she underwent emergency endometrial ablation and removal of the tumor that was protruding from the endometrial cavity. Immediately after receiving histological diagnosis, abdominal hysterectomy was performed with bilateral oophorectomy. Considering that the available published literature has only a few reports of MPNST mainly arising from the uterine cervix, with no established treatment, our contribution could help the scientific community in adding data to MPNSTs arising from the uterine body.