Intranasal insulin therapy in the treatment of alzheimer’s disease – A narrative review

IF 0.6 Q3 Medicine

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2023-05-15 DOI:10.18231/j.ijashnb.2023.006

A. Nene, Jenifer Rodriguez Santoni

引用次数: 0

Abstract

The administration of intranasal insulin improves symptoms related to Alzheimer’s disease. The research was conducted through a hypothesis-based review, such as, PubMed, DynaMed, and EBSCOhost. The articles published between 2011 and 2020 were included. The studies included randomized controlled trials and cohort studies. The study populations included participants associated with cognitive-related conditions. The group of humans and animal models were also considered. All ten articles showed how the administration of intranasal insulin can improve the symptoms related to Alzheimer’s disease. However, these findings varied on the level of dose used, the duration of the treatment and the type of insulin formulations used. Future studies can consider to provide a more homogenous group of study population, cognitive-related activities to observe, and duration of the administration in order to provide a more credible result.

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鼻内胰岛素治疗阿尔茨海默病的研究综述

鼻内注射胰岛素可改善阿尔茨海默病相关症状。本研究通过PubMed、DynaMed和EBSCOhost等基于假设的综述进行。收录了2011年至2020年间发表的文章。这些研究包括随机对照试验和队列研究。研究人群包括患有认知相关疾病的参与者。还考虑了人类和动物模型组。这10篇文章都显示了鼻内注射胰岛素如何改善阿尔茨海默病的相关症状。然而，这些结果在使用的剂量水平、治疗持续时间和使用的胰岛素制剂类型上有所不同。未来的研究可以考虑提供一个更均匀的研究人群、观察认知相关活动和给药时间，以提供更可信的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.90

自引率

0.00%

发文量

226

审稿时长

3 months

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.