Lindita Ibrahimi, M. Paçarada, Syheda Latifi Hoxha, A. Bimbashi, Vlora Ademi Ibishi
{"title":"Role of Calcium/Creatinine Ratio in Urine Compared with Proteinuria and Uric Acid in Predicting Preeclampsia: A Study from Kosovo","authors":"Lindita Ibrahimi, M. Paçarada, Syheda Latifi Hoxha, A. Bimbashi, Vlora Ademi Ibishi","doi":"10.12659/MSMBR.929845","DOIUrl":null,"url":null,"abstract":"Background Preeclampsia is a common complication of pregnancy and a major cause of morbidity and mortality of mothers and babies worldwide. This study aimed to explore what the role of calcium/creatinine ratio is in urine compared with proteinuria and uric acid in predicting preeclampsia. Material/Methods In this prospective case-control study, 200 pregnant women who participated in the study were consecutively divided into 3 groups: a group of 59 women with preeclampsia, 61 women with pregnancy-induced hypertension, and a control group of 80 normotensive pregnant women. A 24-h urine sample was collected for estimation of calcium/creatinine ratio and proteinuria and a blood sample for estimation of uric acid at a gestational age of 24–34 weeks of pregnancy. Results The study found that the sensitivity of proteinuria as a predictor of preeclampsia was 96.6% (P=0.000) and specificity was 21.3%. The sensitivity of uric acid as a predictor was 96.6% (P=0.000) and the specificity was 48.8%; whereas for the 24-h urine calcium/creatinine ratio, the sensitivity was 87.9% (P=0.000) and the specificity 40.7%, which corresponds to a value of 0.105 (cutoff). Women with a calcium/creatinine ratio <0.105 have a higher risk of developing preeclampsia (87.9% confidence interval, P=0.000). Conclusions The role of the calcium/creatinine ratio in urine is inferior to proteinuria and uric acid in predicting preeclampsia.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"234 1","pages":"e929845-1 - e929845-7"},"PeriodicalIF":1.5000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Science Monitor Basic Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12659/MSMBR.929845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 2
Abstract
Background Preeclampsia is a common complication of pregnancy and a major cause of morbidity and mortality of mothers and babies worldwide. This study aimed to explore what the role of calcium/creatinine ratio is in urine compared with proteinuria and uric acid in predicting preeclampsia. Material/Methods In this prospective case-control study, 200 pregnant women who participated in the study were consecutively divided into 3 groups: a group of 59 women with preeclampsia, 61 women with pregnancy-induced hypertension, and a control group of 80 normotensive pregnant women. A 24-h urine sample was collected for estimation of calcium/creatinine ratio and proteinuria and a blood sample for estimation of uric acid at a gestational age of 24–34 weeks of pregnancy. Results The study found that the sensitivity of proteinuria as a predictor of preeclampsia was 96.6% (P=0.000) and specificity was 21.3%. The sensitivity of uric acid as a predictor was 96.6% (P=0.000) and the specificity was 48.8%; whereas for the 24-h urine calcium/creatinine ratio, the sensitivity was 87.9% (P=0.000) and the specificity 40.7%, which corresponds to a value of 0.105 (cutoff). Women with a calcium/creatinine ratio <0.105 have a higher risk of developing preeclampsia (87.9% confidence interval, P=0.000). Conclusions The role of the calcium/creatinine ratio in urine is inferior to proteinuria and uric acid in predicting preeclampsia.