Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial

IF 0.4 Q4 ONCOLOGY
H. Eslami, Z. Jamali, H. Babaei, Vahid Fakhrzadeh, Javad Ahamdi, F. Tavakoli
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引用次数: 1

Abstract

Background: Mucositis is one of the most important complications of radiotherapy. Some factors such as type of treatment and degree of patient sensitivity affect mucositis occurrence. Objective: This research was implemented to evaluate the effect of grape seed extract on radiation-induced mucositis. Methods: This research is a double-blinded randomized clinical trial implemented on 78 patients undergoing head and neck radiotherapy in the oncology ward of Imam Reza Hospital of Tabriz. The patients were randomly divided into 2 groups, the intervention, and the control group. Each group included 39 patients. The intervention group used 2% grape seed extract mouthwashes and the control group used placebo mouthwashes. The mouthwashes were used 3 times a day for 2 weeks. For statistical analysis of collected data, SPSS 20 software was applied. Results: The results showed that according to the Friedman test, on the 10th and 14th days, mucositis grade and incidence had a significant difference between the intervention and control groups. Conclusions: The findings indicated that grape seed extract mouthwash in preventing radiation-induced mucositis was more effective than a placebo. Thus, this agent can be recommended as an appropriate medication to eliminate oral mucositis symptoms.
评价葡萄籽提取物(GSE)对头颈部放疗史患者口腔黏膜炎的影响-一项随机临床试验
背景:粘膜炎是放射治疗最重要的并发症之一。治疗方式、患者敏感程度等因素影响粘膜炎的发生。目的:探讨葡萄籽提取物对放射性粘膜炎的治疗作用。方法:本研究是一项双盲随机临床试验,对大不里士伊玛目礼萨医院肿瘤病房接受头颈部放疗的78例患者进行研究。将患者随机分为干预组和对照组。每组39例。干预组使用2%葡萄籽提取物漱口水,对照组使用安慰剂漱口水。漱口水每天使用3次,持续2周。采用SPSS 20软件对收集到的数据进行统计分析。结果:根据Friedman检验,在第10天和第14天,干预组与对照组的粘膜炎等级和发病率有显著性差异。结论:葡萄籽提取物漱口水对放射性黏膜炎的预防效果优于安慰剂。因此,本品可作为消除口腔黏膜炎症状的适当药物推荐使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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