Evaluation of the Hepatic effects of Caladium hortulanum Leaf Extract on Wistar Albino Rats

G. A. Oforibika, C. Obia
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Abstract

This study evaluates the hepatic effects of caladium hortulanum leaf extract on wistar albino rats. A total of twenty-four (24) rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well-ventilated room.  Group A served as control and these rats were fed distilled water. Rats in the groups B, C, and D were given three (3) different doses of the leaf extract (1.5, 3.5 and 5.0mL/Kgbw) respectively. They were administered once daily for 14 and 28 days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. All liver enzymes and histology results were normal for short term use in this study. Alkaline phosphatase was increased in a dose dependent manner when used in the long term. Histopathological changes were seen in all doses when Caladium hortulanum leaf extract was used in the long term. This suggests that this medicinal plant cause some degree of hepatic damage when used for continuously for long periods at a time. Care should therefore be taken with their use, prescriptions reviewed as needed and regular monitoring of liver function should be instituted.
荆芥叶提取物对Wistar白化大鼠肝脏作用的评价
本研究评价了花楸叶提取物对wistar白化大鼠肝脏的影响。24只大鼠随机分为A、B、C、D 4组,置于通风良好的室内。A组为对照组,用蒸馏水喂养。B、C、D组大鼠分别给予3种不同剂量的叶提取物(1.5、3.5、5.0mL/Kgbw)。每日1次,连续用药14、28 d。最后一次治疗后24小时处死动物。血样采集到肝素化样瓶中进行分析。所有肝酶和组织学结果在本研究中短期使用正常。碱性磷酸酶在长期使用时呈剂量依赖性增加。长期使用金花莲叶提取物后,各剂量小鼠均出现组织病理学变化。这表明,如果长时间连续使用,这种药用植物会对肝脏造成一定程度的损害。因此,应谨慎使用,根据需要审查处方,并应建立定期监测肝功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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