A Review on the many different types of Polymers that are Utilized in the Production of in Situ Gels

Abstract

Gels formed in situ have quickly emerged as one of the most widely used and easily accessible methods. These systems have a number of advantages, including simple production, ease of use, enhanced adherence, and patient comfort by limiting the amount of times drugs need to be administered due to its one-of-a-kind characteristics, which include a sol-to-gel transition. The precursor is subjected to hydrolysis as well as polymerization or condensation in the ‘sol-gel' process, which ultimately results in the production of a colloidal suspension or solution. In spite of the fact that these in situ gelling systems can be administered in solution form, the gelation process takes place at the achievement site. Recent years have seen the development of in situ gelling systems for liposomes, microspheres, nanoemulsions, nanospheres, and other similar structures by a few researchers. This review primarily concentrated on the introduction, followed by a discussion of the benefits, drawbacks, different types of polymers, and desirable qualities for the preparation of in situ gels.