Multisystem inflammatory syndrome in a child associated with COVID-19: a clinical case report

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
N. S. Kosmynina, M. Dats-Opoka
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引用次数: 0

Abstract

Multisystem inflammatory syndrome in children (MIS-C) who contracted COVID-19 remains an urgent problem. Mortality due to this disease among children ranges from 0.8 % to 2.0 %. According to reports found in the literature, MIS-C can develop both in children who have experienced COVID-19 without clinical manifestations, and in those who have had a severe course of the disease. To date, there are no well-defined factors that allow predicting the risk of developing MIS-C in children after experiencing COVID-19, and the spectrum of clinical manifestations can be quite diverse. Aim: on the example of a specific case, to examine and analyze the features of the course and the range of diagnostic measures in children with MIS-C using an analytical method and a systemic approach. Materials and methods. The material was a clinical case of MIS-C, methods of instrumental diagnosis and objective analysis. The diagnosis of MIS-C was based on the WHO 2021 criteria for the diagnosis of MIS-C associated with COVID-19. Results. The clinical case of MIS-C associated with COVID-19 in a child with congenital thymus pathology that resulted in rapid, aggressive, and worsening multiple organ failure was studied. The manifestations were dominated by liver failure, respiratory failure, circulatory failure, and neurological deficiency, that led to the child’s death. Conclusions. Multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection can lead to serious and life-threatening complications in previously clinically healthy children. Physicians need to be more alert to children of different age groups with manifestations of respiratory infections as potential COVID-19 and to test for its presence, which will subsequently allow timely identification of children with MIS-C associated with SARS-CoV-2. Considering the probable role of the thymus in the pathogenesis and course of MIS-C associated with SARS-CoV-2, we recommend an ultrasound examination of the thymus for all children under 3 years of age with confirmed COVID-19 and followed by examination of T-cellular response if changes are detected.
1例与COVID-19相关的儿童多系统炎症综合征:临床病例报告
感染COVID-19的儿童多系统炎症综合征(MIS-C)仍然是一个紧迫的问题。这种疾病在儿童中的死亡率为0.8%至2.0%。根据文献中发现的报告,在没有临床表现的COVID-19儿童和那些有严重病程的儿童中,MIS-C都可能发生。迄今为止,还没有明确的因素可以预测儿童在经历COVID-19后患miss - c的风险,而且临床表现的范围可能相当多样化。目的:以具体病例为例,运用分析方法和系统方法,考察和分析misc患儿病程特点和诊断措施范围。材料和方法。材料为临床一例misc,仪器诊断方法及客观分析。根据世卫组织2021年与covid -19相关的MIS-C诊断标准进行诊断。研究了1例先天性胸腺病理导致快速、侵袭性、加重的多器官衰竭的misc合并COVID-19患儿的临床病例。主要表现为肝功能衰竭、呼吸衰竭、循环衰竭和神经功能障碍,最终导致患儿死亡。与SARS-CoV-2感染相关的儿童多系统炎症综合征可导致先前临床健康的儿童出现严重和危及生命的并发症。医生需要对有呼吸道感染表现的不同年龄组儿童提高警惕,并检测其是否存在,从而及时识别与SARS-CoV-2相关的misc儿童。考虑到胸腺在SARS-CoV-2相关的MIS-C发病机制和病程中可能发挥的作用,我们建议对所有确诊COVID-19的3岁以下儿童进行胸腺超声检查,如果检测到变化,随后检查t细胞反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
72
审稿时长
8 weeks
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