FEATURES OF THE ETIOLOGICAL STRUCTURE OF NON-POLIO ENTEROVIRUS INFECTION IN CHILDREN IN THE PRE-PANDEMIC AND POST-PANDEMIC PERIODS

Abstract

Annotation Justification. Registration of regional features of the etiological structure of non-polio enterovirus infection (NPEVI) in children in the pre-pandemic and post-pandemic periods. Goal. To determine the features of the etiological structure of non-polio enterovirus infection in children in the pre-pandemic and post-pandemic periods in the Khanty-Mansiysk Autonomous Okrug. Materials and methods. The data from the forms of statistical observation for 2013-2022 and the results of molecular genetic studies of the structure of NPEVI in children in the pre-pandemic and post-pandemic periods were used. Results. The tendency of the increase in the incidence of NPEVI in the Khanty-Mansi Autonomous Okrug in the period before the COVID-19 pandemic with a predominance of the proportion of children under 6 years old has been established. In the study period up to 2019, enteroviruses (EV) Coxsackie A6 in combination with EV A71 dominated, for which the calculated trends of the short-term forecast were confirmed in 2022. In the same year, these EVs were the most common cause of focal diseases with exanthemic forms of NPEVI. In 2022, the circulation of 8 more EV genovariants was recorded, among which Coxsackie A10 EV prevailed (20.5% of cases), which caused the majority of cases of enterovirus vesicular pharyngitis. 5 cases of enterovirus meningitis (11,%) were registered in children with the release of ESNO6, ESNO9, Coxsackie A9, which were not noted in other clinical forms and circulated irregularly and in smaller numbers during the pre-pandemic period than in 2022. Conclusion. The analysis of the monitoring data of the NPEVI in the territory of the Khanty-Mansi Autonomous Okrug revealed a trend of gradual increase in the incidence of children, which must be taken into account when organizing epidemiological surveillance of the NPEVI. The completeness of the registration of cases of NPEVI with mandatory genotyping of the detected EV strains will allow to more accurately determine the spectrum of strains endemic to this territory and assess the probability of their spread in order to make a forecast about the true level of morbidity, conduct appropriate scientifically based anti-epidemic and preventive measures among the children of the Khanty-Mansi Autonomous Okrug-Yugra.