Propyl homologue of tetrahydrocannabinol: its isolation from Cannabis, properties, and synthesis

Abstract

The n-propyl homologue of Δ1-tetrahydrocannabinol (Δ1-THC) has been isolated from Cannabis sativa L. The structure of the compound was deduced by i.r., n.m.r., and mass spectroscopy, and was confirmed by synthesis. It has only one-fifth of the activity of Δ1-THC in the mouse catalepsy test, and although present in amounts comparable to Δ1-THC it probably makes only a small contribution to the effects produced by the consumption of crude cannabis.