Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis

Annals of Otology, Rhinology & Laryngology Pub Date : 2020-03-01 DOI:10.1177/0003489419885403

Jonathan K. Lin, L. Sakoda, J. Darbinian, Melissa Socarras, Whitney Chiao, Nathaniel E Calixto, C. Quesenberry, D. Gurushanthaiah, Kevin H Wang, M. Durr

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引用次数: 5

Abstract

Objectives: To examine the association between treatment status and mortality risk among patients with papillary thyroid cancer (PTC). Methods: We identified 3,679 adults with PTC. Thirty-one untreated patients were matched to 155 treated patients. Hazards ratios (HR) and 95% confidence intervals (CIs) were calculated to estimate all-cause and disease-specific mortality. A low-risk subgroup was analyzed for differences in all-cause mortality. Results: The adjusted HRs (95% CIs) for all-cause mortality at 5 and 10 years were 4.2 (1.7-10.3) and 4.1 (1.9-9.4) and for disease- specific mortality were 14.1 (3.4-59.3) and 10.2 (2.9-36.4), respectively, for untreated versus treated patients. The adjusted HRs (95% CIs) for all- cause mortality was 0.7 (0.1-6.4) for low-risk untreated versus matched treated patients. Conclusions: Compared to treated patients, untreated PTC patients were at higher risk of death while low-risk untreated PTC patients had comparable rate of metastasis and no increased risk of all-cause mortality. Level of evidence: 3

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未经治疗和治疗的甲状腺乳头状癌的死亡风险:一项匹配队列分析

目的:探讨甲状腺乳头状癌(PTC)患者治疗状况与死亡风险之间的关系。方法:我们确定了3679名成人PTC患者。31名未经治疗的患者与155名接受治疗的患者相匹配。计算危险比(HR)和95%置信区间(ci)来估计全因死亡率和疾病特异性死亡率。低风险亚组分析全因死亡率的差异。结果:5年和10年全因死亡率的调整hr (95% ci)分别为4.2(1.7-10.3)和4.1(1.9-9.4)，疾病特异性死亡率分别为14.1(3.4-59.3)和10.2(2.9-36.4)。低风险未治疗患者与匹配治疗患者的全因死亡率调整hr (95% ci)为0.7(0.1-6.4)。结论:与接受治疗的患者相比，未经治疗的PTC患者有更高的死亡风险，而低风险的未经治疗的PTC患者有相当的转移率，没有增加全因死亡率的风险。证据等级:3

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of Otology, Rhinology & Laryngology

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