{"title":"Transcutaneous biochemical substance monitoring based on biosensors-blood glucose and lactate","authors":"M. Kikuchi, S. Kayashima, N. Ito, T. Arai","doi":"10.1109/IEMBS.1996.656861","DOIUrl":null,"url":null,"abstract":"New transcutaneous monitoring methods for biochemical substances such as blood glucose and lactate have been developed by using a suction effusion fluid (SEF) collecting technique with an ion-sensitive field-effect transistor for blood glucose, and with a micro-planar amperometric biosensor for lactate respectively. Firstly, blood glucose change during the 75-g oral glucose tolerance test (OGTT) was monitored by suction effusion fluid (SEF) sampling in 5 patients with type II diabetes. Secondly, the authors have also developed a micro planar biosensor for determining lactate concentration in very small sample. The biosensor utilizes a lactate oxidase immobilized membrane on a micro planar platinum electrode to yield a lactate sensor. Both glucose and lactate concentrations measured with SEF showed good correlation with those obtained directly from whole blood.","PeriodicalId":20427,"journal":{"name":"Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IEMBS.1996.656861","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
New transcutaneous monitoring methods for biochemical substances such as blood glucose and lactate have been developed by using a suction effusion fluid (SEF) collecting technique with an ion-sensitive field-effect transistor for blood glucose, and with a micro-planar amperometric biosensor for lactate respectively. Firstly, blood glucose change during the 75-g oral glucose tolerance test (OGTT) was monitored by suction effusion fluid (SEF) sampling in 5 patients with type II diabetes. Secondly, the authors have also developed a micro planar biosensor for determining lactate concentration in very small sample. The biosensor utilizes a lactate oxidase immobilized membrane on a micro planar platinum electrode to yield a lactate sensor. Both glucose and lactate concentrations measured with SEF showed good correlation with those obtained directly from whole blood.