Focal Cortical Dysplasia as Cause of Refractory Epilepsy- A Case Report

Sujan Saha, Md Abdullah Al Muzahid, A. Chowdhury, M. Hasan, Uttam Roy, Md Suman Kabir, Md. Rafiqul Islam
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Abstract

Focal Cortical Dysplasia (FCD) is one of the most common causes of refractory epilepsy in children as well as adult where malformed cortical development occurs resulting from abnormal neuronal migration due to both genetic and acquired factors. Herein, a 22-year-old male presented with recurrent secondary generalized tonic seizure with aura since childhood. Despite adequate anti-epileptic medications with good compliance the seizure was uncontrolled. As a cause, Type II FCD was diagnosed by specific neuroimaging findings supported by EEG abnormalities. Till now in refractory epilepsy FCD is rarely diagnosed but there remains a good hope of cure by surgical intervention. Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 46-50
顽固性癫痫致局灶性皮质发育不良1例报告
局灶性皮质发育不良(FCD)是儿童和成人难治性癫痫最常见的原因之一,其中由于遗传和后天因素导致的异常神经元迁移导致皮质发育畸形。本文报告一位22岁男性,自孩童时期以复发性继发性全身性强直性癫痫发作为先兆。尽管服用了适当的抗癫痫药物,但癫痫发作未得到控制。作为病因,II型FCD是由脑电图异常支持的特定神经影像学结果诊断的。迄今为止,难治性癫痫中FCD很少被诊断出来,但仍有很好的希望通过手术治疗。2019年孟加拉国神经科学杂志;Vol. 35 (1): 46-50
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