The protein-nanoparticle interaction (protein corona) and its importance on the therapeutic application of nanoparticles

M. Sedighi, M. Shakibaie
{"title":"The protein-nanoparticle interaction (protein corona) and its importance on the therapeutic application of nanoparticles","authors":"M. Sedighi, M. Shakibaie","doi":"10.32592/jbirjandunivmedsci.2021.28.4.100","DOIUrl":null,"url":null,"abstract":"Nanobiotechnology has provided promising novel diagnostic and therapeutic strategies which capable to create a broad spectrum of nano-based imaging agents and medicines for human administrations. Several studies have demonstrated that the surface of nanomaterials is immediately coated with suspended proteins after contact with plasma or other biological fluids to form protein corona-nanoparticle complexes. Cells react after exposure with these complexes. since, the biological fate and functions of nanomaterials are determined by physiological responses to protein -nanoparticle complexes in this article, we aimed to review some studies about the effects of the protein profiles and physicochemical characteristics of nanoparticles in the biological environment on the formation of protein corona and subsequent the biological responses upon exposure to nanoparticles. Also, some used methods for of protein corona analysis has been reviewed. It has been shown that the biological impacts of protein corona may be both constructive and/or destructive in the biomedical applications of nanomaterials. The protein corona–cell interactions can facilitate targeted delivery and cellular absorption of therapeutic nanomaterials and also, they mitigate the unfavorable cytotoxic effects of nanoparticles. On the other hand, these interactions may cause rapid clearance of nanoparticles from the body as well as the activation of undesirable inflammatory responses. Hence, the study of the formation mechanism and biological effects of protein corona plays an important role in the design of nanoparticles with specific physicochemical properties proportional with their intended biological activity.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Birjand University of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32592/jbirjandunivmedsci.2021.28.4.100","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Nanobiotechnology has provided promising novel diagnostic and therapeutic strategies which capable to create a broad spectrum of nano-based imaging agents and medicines for human administrations. Several studies have demonstrated that the surface of nanomaterials is immediately coated with suspended proteins after contact with plasma or other biological fluids to form protein corona-nanoparticle complexes. Cells react after exposure with these complexes. since, the biological fate and functions of nanomaterials are determined by physiological responses to protein -nanoparticle complexes in this article, we aimed to review some studies about the effects of the protein profiles and physicochemical characteristics of nanoparticles in the biological environment on the formation of protein corona and subsequent the biological responses upon exposure to nanoparticles. Also, some used methods for of protein corona analysis has been reviewed. It has been shown that the biological impacts of protein corona may be both constructive and/or destructive in the biomedical applications of nanomaterials. The protein corona–cell interactions can facilitate targeted delivery and cellular absorption of therapeutic nanomaterials and also, they mitigate the unfavorable cytotoxic effects of nanoparticles. On the other hand, these interactions may cause rapid clearance of nanoparticles from the body as well as the activation of undesirable inflammatory responses. Hence, the study of the formation mechanism and biological effects of protein corona plays an important role in the design of nanoparticles with specific physicochemical properties proportional with their intended biological activity.
蛋白质-纳米粒子相互作用(蛋白质电晕)及其在纳米粒子治疗应用中的重要性
纳米生物技术提供了有前途的新型诊断和治疗策略,能够创造广泛的纳米成像剂和人类用药。几项研究表明,纳米材料与等离子体或其他生物液体接触后,表面立即被悬浮的蛋白质包裹,形成蛋白质冠状纳米颗粒复合物。细胞与这些复合物接触后发生反应。由于纳米材料的生物学命运和功能是由蛋白质-纳米颗粒复合物的生理反应决定的,本文旨在综述生物环境中纳米颗粒的蛋白质谱和物理化学特性对蛋白质电晕形成和随后暴露于纳米颗粒后的生物反应的影响。并对目前常用的蛋白质冠分析方法进行了综述。研究表明,在纳米材料的生物医学应用中,蛋白质冠的生物影响可能是建设性的,也可能是破坏性的。蛋白质冠状细胞相互作用可以促进治疗性纳米材料的靶向递送和细胞吸收,同时也可以减轻纳米颗粒的不利细胞毒性作用。另一方面,这些相互作用可能导致纳米颗粒从体内迅速清除,以及激活不希望的炎症反应。因此,研究蛋白质电晕的形成机制和生物学效应对于设计具有与其预期生物活性成正比的特定物理化学性质的纳米颗粒具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
审稿时长
18 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信