Experimental study about the protective effect of propofolon on acute renal ischemia reperfusion injury in rats

实用医技杂志 Pub Date : 2007-01-01 DOI:10.3760/CMA.J.ISSN.1673-4416.2010.05.016

Yanbin Song, Jan Sun, Jan Liu

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Abstract

Objectives To investigate the renal protection and mechanism of propofol in acute renal ischemia reperfusion injury(ARIRI) rat models. Methods The model of rat's ARIRI was established. 63SD rats were randomly divided into 3 groups: false operating group(A group), ischemia reperfusion group (B group) and propofoi group(C group). Blood urea nitrogen (BUN), creatinine (Cr), superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were detected before I/R (Ischemic reperfusion) for 15 minutes and after I/R for2 hours and 24 hours, and renal histopathology lesions were examined.Results Renal histopathology lesions of Propofol preconditioning group decreased significantly after ischemia reperfusion. In L/R group, BUN and Cr serum levels increased significantly after ischemia reperfusion compared with false operating group(p ＜0.05), while propofol decreased the serum levels of BUN and Cr significantly (p ＜0.05). There was statistic significance of the serum levels of SOD, MDA, TNF-a and IL-6 in Propofol preconditioning group and ischemia reperfusion group (p ＜ 0.05). Conclusions Propofol preconditioning to kidney could protect the kidney from acute renal ischemia reperfusion injury. Key words: Kidney; Reperfusion; Rats; Phenols

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异丙酚对大鼠急性肾缺血再灌注损伤保护作用的实验研究

目的探讨异丙酚对急性肾缺血再灌注损伤(ARIRI)模型大鼠肾脏的保护作用及其机制。方法建立大鼠ARIRI模型。将63SD大鼠随机分为3组:假手术组(A组)、缺血再灌注组(B组)、异丙酚组(C组)。在缺血再灌注前15分钟、缺血再灌注后2小时、24小时检测血尿素氮(BUN)、肌酐(Cr)、超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)，并检查肾脏组织病理学病变。结果异丙酚预处理组缺血再灌注后肾组织病理病变明显减少。L/R组缺血再灌注后血清BUN、Cr水平显著高于假手术组(p <0.05)，异丙酚显著降低血清BUN、Cr水平(p <0.05)。异丙酚预处理组与缺血再灌注组大鼠血清SOD、MDA、TNF-a、IL-6水平比较，差异均有统计学意义(p < 0.05)。结论异丙酚预处理对急性肾缺血再灌注损伤有保护作用。关键词:肾;再灌注;大鼠;酚类

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实用医技杂志

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期刊介绍： "Journal of Practical Medical Techniques" magazine was officially launched in 1994 with the approval of the State Administration of Press and Publication. The magazine has a wide coverage at home and abroad, with novel topics, large amount of information and strong timeliness. The main columns include: pathological diagnosis, mental health, clinical nursing, etc. "Journal of Practical Medical Techniques" magazine targets medical, medical technology, management and nursing personnel in medical and health units, medical schools, military factories and mines hospitals as the main readers. It reports leading scientific research results and clinical diagnosis and treatment, medical technology experience in the fields of medical and medical technology, as well as basic theoretical research that has a guiding role in clinical practice and is closely integrated with medical and medical technology.