New Technology for DNA Chips on a Microarray-Random Fluidic Self-assembly Method Using Hydrophobic Interaction

Abstract

Abstract In this paper, we describe a new approach for an arrangement of many kinds of DNAs on transducers to construct a DNA microarray. A high-density array of sensor probes was prepared by randomly distributing a mixture of particles immobilized with various DNAs. A process for immobilization of the DNAs was separated from the assembly of the particles. The particles were arranged on the chip pattern by random fluidic self-assembly, using hydrophobic interaction.