ANTI-INFLAMMATORY EFFECTS OF Channa micropeltes EXTRACT TOWARDS INTERLEUKIN-10 IN DIABETIC RAT

Dentino Jurnal Kedokteran Gigi Pub Date : 2022-10-28 DOI:10.20527/dentino.v7i2.14628

A. N. Carabelly, Juliyatin Putri Utami, Didit Aspriyanto, Milka Widya Sari, Erika Norfitriyah

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Abstract

Background: Inhibition of tissue repair is a symptom of prolonged diabetic inflammation that occurs in wounds resulting in delayed healing. Inflammation can be controlled by giving food supplements that have anti-inflammatory properties such as Channa micropeltes (CM). CM has high protein content, including albumin, omega 3 and omega 6 fatty acids, vitamin C, and zinc. Purpose: This study aimed to analyse the effect of the CM extract on the levels of IL-10 in the wound healing process of normal and diabetic rats. Methods: This study was a true experimental design with a post-test-only control group design. The samples were the diabetic model group given CM extract at 16 mL/kg BB dose and negative control group for 14 days. Results: Compared to the control, the concentration of IL-10 in DM group was significantly higher in the DM without CM treatment. Interestingly, we found the level of IL-10 in DM-CM was significantly decreased while the level of TNF-a in DM-CM decreased as well. Conclusion: CM at a dose of 16 mL/kg BW for 14 days in the wound healing process of Wistar rats can increase IL-10 in the normal group but could not increase IL-10 in the diabetic group. Keywords: Anti-inflammatory, Channa micropeltes, Diabetes, Interleukin-10.

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木瓜微球提取物对糖尿病大鼠白细胞介素-10的抗炎作用

背景:组织修复抑制是糖尿病性炎症导致伤口延迟愈合的一种症状。炎症可以通过服用具有抗炎特性的食物补充剂来控制，比如钱娜微球(CM)。CM的蛋白质含量高，包括白蛋白、欧米伽3和欧米伽6脂肪酸、维生素C和锌。目的:分析中药提取物对正常和糖尿病大鼠创面愈合过程中IL-10水平的影响。方法:本研究采用真正意义上的实验设计，采用单纯测试后对照组设计。糖尿病模型组以16 mL/kg BB剂量给予CM提取物，阴性对照组给予14 d。结果:与对照组相比，未治疗CM的DM组IL-10浓度显著升高。有趣的是，我们发现DM-CM中IL-10水平显著降低，而TNF-a水平也显著降低。结论:在Wistar大鼠创面愈合过程中，CM剂量为16 mL/kg BW，持续14 d，可使正常组IL-10升高，而不能使糖尿病组IL-10升高。关键词:抗炎，微球，糖尿病，白细胞介素-10

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Dentino Jurnal Kedokteran Gigi

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审稿时长

24 weeks