Amniotic membrane transplantation in diabetic corneal ulcer

中国实用眼科杂志 Pub Date : 2017-06-10 DOI:10.3760/CMA.J.ISSN.1006-4443.2017.06.020

Zhi-qin Wu, Yanning Yang, Jing Yuan

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Abstract

Objective To evaluate the effects of amniotic membrane transplantation in refractory corneal ulcer accompanied with diabetes mellitus. Methods Sixteen patients with refractory diabetic corneal ulcer from March 2010 to February 2016 were included in this study. All patients were giv-en cornea scraping and microbial cultivation to exclude bacteria, fungal and amoebal infection. After strengthen controlling the blood sugar, all patients received amniotic membrane transplantation. According to the depth of the ulcer, the patient received a single layer or multi-layer amniotic membrane transplantation. Outcomes measured included corneal ulcer healing, best corrected visual acuity (BCVA) and complications. The follow-up period was 4-16 months. Results One patient received amniotic membrane transplantation twice. The corneal ulcer resolved in 16 patients in 2 weeks to 2 months postoperatively and formed macula or leukoma. At the last visit, BCVA was improved in all patients. There was no serious complication in the follow-up. Conclusions Amniotic membrane transplantation can effectively promote corneal healing. It is an effect treatment for refractory diabetic corneal ulcer. Key words: Diabetic keratopathy; Corneal ulcer; Amniotic membrane transplantation

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羊膜移植治疗糖尿病性角膜溃疡

目的探讨羊膜移植治疗难治性角膜溃疡合并糖尿病的疗效。方法选取2010年3月至2016年2月收治的16例难治性糖尿病性角膜溃疡患者。所有患者均行角膜刮痧和微生物培养，以排除细菌、真菌和阿米巴原虫感染。在加强血糖控制后，所有患者均行羊膜移植。根据溃疡的深度，对患者进行单层或多层羊膜移植。测量的结果包括角膜溃疡愈合、最佳矫正视力(BCVA)和并发症。随访4 ~ 16个月。结果1例患者接受两次羊膜移植。16例患者术后2周至2个月角膜溃疡消退，形成黄斑或白斑。最后一次访问时，所有患者的BCVA均有所改善。随访无严重并发症发生。结论羊膜移植可有效促进角膜愈合。是治疗难治性糖尿病性角膜溃疡的有效方法。关键词:糖尿病性角膜病变;角膜溃疡;羊膜移植

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中国实用眼科杂志

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9101

期刊介绍： China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association. China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.