Role of Fluorine-18-Fluorodeoxyglucose in the Work-up of Febrile AIDS Patients

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 1999-11-01 DOI:10.1016/S1095-0397(99)00036-9

Jonas F. Santiago MD , Suman Jana MD , Holly M. Gilbert MD , Shahenda Salem MD , Paul Curtis Bellman MD , Ricky K.S. Hsu MD , Sleiman Naddaf MD , Hussein M. Abdel-Dayem MD

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引用次数: 15

Abstract

Objective and Methods: This study was undertaken to find the role of fluorine-18-fluorodeoxyglucose (F18-FDG) in the diagnostic work-up of febrile Acquired Immune Deficiency Syndrome (AIDS) patients. Forty-seven (42 male and 5 female; mean age = 40.3 years) febrile patients with AIDS underwent imaging with F18-FDG by Dual Head Coincidence Imaging (DHCI). Findings were correlated with other imaging modalities.

Results: Our data show good sensitivity for scanning with F18-FDG by DHCI in determining the extent of Castleman's disease, lymphoma, Kaposi's sarcoma (KS), adenocarcinoma, and germ cell carcinoma. Various opportunistic infections also manifest with increased F18-FDG uptake.

Conclusion: Total-body imaging can be done with F18-FDG with better resolution and a shorter procedure time compared to imaging with Gallium-67 (Ga-67). Furthermore, F18-FDG is more sensitive than Ga-67 for evaluating extent of involvement in various pathologies affecting AIDS patients. The new technology of DHCI is a good alternative for hospitals with no dedicated positron emission tomography (PET) scanner.

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氟-18氟脱氧葡萄糖在发热性艾滋病患者治疗中的作用

目的与方法：探讨氟-18氟脱氧葡萄糖（F18-FDG）在发热性获得性免疫缺陷综合征（AIDS）诊断检查中的作用。47名（42名男性和5名女性；平均年龄=40.3岁）发热性艾滋病患者接受了F18-FDG双探头符合成像（DHCI）成像。研究结果与其他成像方式相关。结果：我们的数据显示，DHCI用F18-FDG扫描在确定Castleman病、淋巴瘤、Kaposi肉瘤（KS）、腺癌和生殖细胞癌的程度方面具有良好的敏感性。各种机会性感染也表现为F18-FDG摄取增加。结论：与镓-67（Ga-67）成像相比，F18-FDG可以进行全身成像，具有更好的分辨率和更短的手术时间。此外，在评估影响艾滋病患者的各种病理的程度方面，F18-FDG比Ga-67更敏感。DHCI的新技术对于没有专用正电子发射断层扫描（PET）扫描仪的医院来说是一个很好的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical positron imaging : official journal of the Institute for Clinical P.E.T

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