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{"title":"The Neonatal Ventral Hippocampal Lesion (NVHL) Rodent Model of Schizophrenia","authors":"Anne Marie Brady","doi":"10.1002/cpns.15","DOIUrl":null,"url":null,"abstract":"<p>Animal models are crucial to the study of the neurobiological bases of psychiatric disorders, but schizophrenia is a particularly challenging disorder to model given the complexity and heavily verbal nature of its symptoms. This unit describes a developmental surgical rodent model of schizophrenia, the neonatal ventral hippocampal lesion (NVHL) model. This widely used model produces reliable behavioral abnormalities that are comparable to those observed in patients, as well as anatomical and neurophysiological disruptions in forebrain areas that are also implicated in schizophrenia. A brief background of the development and validity of the NVHL model is discussed here, along with detailed procedures for producing the model in rats. Critical issues particular to neonatal surgery are discussed, and representative histological and behavioral results are presented. © 2016 by John Wiley & Sons, Inc.</p>","PeriodicalId":40016,"journal":{"name":"Current Protocols in Neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cpns.15","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Protocols in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cpns.15","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 14
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Abstract
Animal models are crucial to the study of the neurobiological bases of psychiatric disorders, but schizophrenia is a particularly challenging disorder to model given the complexity and heavily verbal nature of its symptoms. This unit describes a developmental surgical rodent model of schizophrenia, the neonatal ventral hippocampal lesion (NVHL) model. This widely used model produces reliable behavioral abnormalities that are comparable to those observed in patients, as well as anatomical and neurophysiological disruptions in forebrain areas that are also implicated in schizophrenia. A brief background of the development and validity of the NVHL model is discussed here, along with detailed procedures for producing the model in rats. Critical issues particular to neonatal surgery are discussed, and representative histological and behavioral results are presented. © 2016 by John Wiley & Sons, Inc.
新生儿腹侧海马损伤（NVHL）精神分裂症啮齿动物模型的建立
动物模型对于研究精神疾病的神经生物学基础至关重要，但鉴于精神分裂症症状的复杂性和高度语言性，它是一种特别具有挑战性的疾病。本单元描述了一种精神分裂症的发育性外科啮齿动物模型，即新生儿腹侧海马损伤（NVHL）模型。这种广泛使用的模型产生了可靠的行为异常，与在患者身上观察到的行为异常相当，前脑区域的解剖和神经生理学破坏也与精神分裂症有关。这里讨论了NVHL模型的发展和有效性的简要背景，以及在大鼠中产生该模型的详细程序。讨论了新生儿手术特有的关键问题，并介绍了具有代表性的组织学和行为学结果。©2016，作者：John Wiley&；股份有限公司。
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