Pencil graphite electrode as an electrochemical sensor for the voltammetric determination of chlorpromazine

IF 6.8 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Science: Advanced Materials and Devices Pub Date : 2018-06-01 DOI:10.1016/j.jsamd.2018.03.007

H.T. Purushothama, Y. Arthoba Nayaka, M.M. Vinay, P. Manjunatha, R.O. Yathisha, K.V. Basavarajappa

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引用次数: 67

Abstract

A selective, simple and sensitive electrochemical sensor has been developed using pencil leads (pencil graphite electrode, PGE) for the investigation of chlorpromazine (CPZ). The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were employed to study the anodic behaviour of CPZ. The bare PGE showed good electrocatalytic activity towards the determination of CPZ in comparison with alanine and glycine modified PGEs. The PGE showed a well enhanced peak current compared to alanine and glycine modified PGEs for the determination of CPZ. The electroactive surface area, influence of pH, effect of scan rate, electron transfer kinetics and sensitivity have been studied. DPV has shown good linearity in the concentration range of 0.01 μM – 0.08 μM with the limit of detection of 0.003 μM. The proposed sensor has been successfully employed for the determination of CPZ present in a pharmaceutical sample.

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铅笔石墨电极电化学传感器伏安法测定氯丙嗪

用铅笔芯（铅笔石墨电极，PGE）研制了一种选择性、简单、灵敏的电化学传感器，用于氯丙嗪（CPZ）的研究。采用循环伏安法（CV）和微分脉冲伏安法（DPV）研究了CPZ的阳极行为。与丙氨酸和甘氨酸修饰的PGE相比，裸PGE对CPZ的测定显示出良好的电催化活性。与丙氨酸和甘氨酸修饰的用于测定CPZ的PGE相比，PGE显示出良好增强的峰值电流。研究了电活性表面积、pH值的影响、扫描速率的影响、电子转移动力学和灵敏度。DPV在0.01μM–0.08μM的浓度范围内显示出良好的线性，检测限为0.003μM。所提出的传感器已成功用于测定药物样品中存在的CPZ。

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来源期刊

Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials

CiteScore

11.90

自引率

2.50%

发文量

审稿时长

47 days

期刊介绍： In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.