Tolerancia y efectividad de picosulfato de sodio/magnesio/citrato comparado con polietilenglicol para limpieza intestinal

Abstract

Introduction

Colonoscopy is the preferred procedure in disease of the large bowel, and is considered the reference standard in colorectal cancer detection. Adequate visualisation requires a simple, acceptable, effective, well tolerated bowel preparation, and with minimal adverse effects. The most common method for bowel cleansing is by using polyethylene glycol (PEG). The combination of sodium picosulphate and magnesium citrate (PMC) is gaining popularity as a new agent, but has not been studied extensively. The aim of this study is to compare the quality of bowel cleansing and as well as the tolerance between both preparations using a previous day regimen.

Material and methods

A prospective and randomised trial was conducted with patients being assigned to receive PEG (4 l) or PMC (2 l) the day prior to colonoscopy. Each patient was interviewed to determine their tolerance. The quality of cleaning was evaluated using Boston scale by several endoscopists.

Results

A total of 124 patients were enrolled in the study and 105 were included in the analysis. The mean age was 54.2 ± 14.4 years, and there were 48 (45.7%) male patients and 57 (54.3%) female patients. Nausea, vomiting, abdominal pain, bloating, thirst, dizziness, and headache were evaluated. Nausea was reported more often as a collateral effect in the PEG group (51%, P=.013). The mean score on the Boston scale for PEG group was 7.14 ± 1.31, and for PMC group it was 6.94 ± 1.62. There was no statistically significant difference between both groups (P=.32). Tolerance evaluated using a Likert scale was 4.05 for PEG and 4.47 for PMC, with this difference being significant (P=.014).

Conclusion

This study shows that bowel cleansing with PMC is comparable with PEG in a previous day regimen, and PMC is also better tolerated than PEG.