Study of the pathogenesis and treatment of diabetes mellitus through animal models

Yeray Brito-Casillas , Carlos Melián , Ana María Wägner
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引用次数: 8

Abstract

Most research in diabetes mellitus (DM) has been conducted in animals, and their replacement is currently a chimera. As compared to when they started to be used by modern science in the 17th century, a very high number of animal models of diabetes is now available, and they provide new insights into almost every aspect of diabetes. Approaches combining human, in vitro, and animal studies are probably the best strategy to improve our understanding of the underlying mechanisms of diabetes, and the choice of the best model to achieve such objective is crucial. Traditionally classified based on pathogenesis as spontaneous or induced models, each has its own advantages and disadvantages. The most common animal models of diabetes are described, and in addition to non-obese diabetic mice, biobreeding diabetes-prone (BB-DP) rats, streptozotocin-induced models, or high-fat diet-induced diabetic C57Bl/6J mice, new valuable models, such as dogs and cats with spontaneous diabetes, are described.

糖尿病发病机制及治疗的动物模型研究
大多数关于糖尿病(DM)的研究都是在动物身上进行的,目前它们的替代品是嵌合体。与17世纪现代科学开始使用它们时相比,现在有大量的糖尿病动物模型可用,它们为糖尿病的几乎每个方面提供了新的见解。将人类、体外和动物研究相结合的方法可能是提高我们对糖尿病潜在机制理解的最佳策略,而选择实现这一目标的最佳模型至关重要。传统上根据发病机制分为自发或诱导模型,每种模型都有其优缺点。描述了最常见的糖尿病动物模型,除了非肥胖糖尿病小鼠、生物繁殖糖尿病易发性(BB-DP)大鼠、链脲佐菌素诱导的模型或高脂肪饮食诱导的糖尿病C57Bl/6J小鼠外,还描述了新的有价值的模型,如患有自发性糖尿病的狗和猫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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