Autoimmune Hepatitis

IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Zhou Yuming MD , Tang Ruqi PhD , Merrill Eric Gershwin MD , Ma Xiong MD, PhD
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引用次数: 0
自身免疫性肝炎:病理生理学。
全基因组关联分析表明,包括HLA-DRB*0301、HLA-DRB*4401和HLA-B*3501在内的HLA基因以及包括CD28/CTLA4/ICOS和SYNPR在内的非HLA基因增加了AIH的易感性。肝细胞的破坏是促炎细胞和免疫抑制细胞之间失衡的结果,尤其是Tregs和Th17细胞之间失衡。AIH患者的微生物组多样性降低,双歧杆菌特异性下降,韦氏菌和粪杆菌富集。最近的证据已经证明了鹅膏菌和路氏乳杆菌在诱导肝脏自身免疫中的致病作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinics in liver disease
Clinics in liver disease GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.30
自引率
0.00%
发文量
79
审稿时长
>12 weeks
期刊介绍: A perfect source to consult for those in the fields of gastroenterology and hepatology, Clinics in Liver Disease provides answers to clinical questions, information on the latest diagnostic methods and treatments, and numerous clinical images. Published quarterly—in February, May, August, and November—each issue offers in-depth reviews that focus on the liver and biliary system.
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