Endogenous Metabolites and Genome Instability in Aging and Disease

IF 3.8 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2023-11-10 DOI:10.1021/acs.chemrestox.3c00288

Rachana Tomar*, and , Luke Erber*,

引用次数: 0

Abstract

Proper maintenance of genomic DNA is upheld by tight control of cellular metabolism and DNA processing. Herein, we review recent advances in examining the role of endogenous metabolites and genomic instability in aging and disease as presented at the Fall 2023 American Chemical Society Meeting.

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衰老和疾病中的内源性代谢产物与基因组不稳定性。

通过严格控制细胞代谢和DNA加工来维持基因组DNA的适当维持。在此，我们回顾了在2023年秋季美国化学学会会议上发表的研究内源性代谢物和基因组不稳定性在衰老和疾病中的作用的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.